Alcohol and tobacco are fine, yet presently they cause the most physical and mental damage to humans of any drug. Perhaps the biggest killers of humans on the planet, except for war.
Ecstasy and marijuana don't seem to do much damage, but because of illegality and limited use the potential damage is unknown.
Alcohol and tobacco are massive earners for corporations.
Ecstasy and marijuana only make money for underground drug cartels.
Some are legal.
Some are not.